Synlett 2007(20): 3193-3197  
DOI: 10.1055/s-2007-992381
LETTER
© Georg Thieme Verlag Stuttgart · New York

Diastereoselective Conjugate Radical Additions to β-Pyranones

Mukund P. Sibi*, Arvin Yu
Department of Chemistry, North Dakota State University, Fargo, ND 58105, USA
Fax: Mukund.Sibi@ndsu.edu;
Further Information

Publication History

Received 5 July 2007
Publication Date:
21 November 2007 (online)

Abstract

We have developed a convenient protocol for functionalization of β-pyranones. Conjugate radical addition and tandem addition-trapping protocols allow for accessing highly substituted pyrones in a single operation with high selectivity.

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All new compounds showed analytical and spectral characteristics consistent with their structure. An experimental procedure and spectral data for select products are provided.