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Synfacts 2008(1): 0109-0109
DOI: 10.1055/s-2007-991457
DOI: 10.1055/s-2007-991457
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York
Supported Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling Reactions of Aryl Chlorides
S. Schweizer, J.-M. Becht*, C. Le Drian*
Université de Haute-Alsace, Mulhouse, France
Further Information
Publication History
Publication Date:
18 December 2007 (online)
Significance
An air- and moisture-stable heterogeneous (tert-butylphenylphosphino)polystyrene-supported Pd catalyst 2 was prepared from tert-butylchlorophenylphosphine 1 (eq. 1). The cross-coupling reaction of chlorobenzene and phenyl boronic acids was carried out in the presence of Pd catalyst (0.4 mol%) and CsF as a base in toluene containing 0.3% H2O to give biphenyl 3 in 98% yield (eq. 2). The cross-coupling reactions of a wide range of aryl chlorides with aryl boronic acids were reported (17 examples; 61-98% yield).