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Synfacts 2008(1): 0060-0060  
DOI: 10.1055/s-2007-991429
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Cu(II)-Catalyzed Intramolecular Amination of Terminal Alkenes

Contributor(s): Hisashi Yamamoto, Marina Naodovic
W. Zeng, S. R. Chemler*
The State University of New York, Buffalo, USA
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Publication History

Publication Date:
18 December 2007 (online)

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Significance

This is one of the first reports on enantioselective intramolecular Cu-catalyzed carboamination of olefins. The main significance of this methodology is that it provides easy access to enantiomerically enriched sultams and sulfon­amides, which have key features of many biologically active molecules.