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Synfacts 2007(11): 1116-1116  
DOI: 10.1055/s-2007-991206
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Erypoegin H

Contributor(s): Philip Kocienski, Zofia Komsta
A. Fürstner*, E. K. Heilmann, P. W. Davies
Max-Planck-Institut für Kohlenforschung, Mülheim an der Ruhr, Germany and University of Birmingham, UK
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Publication History

Publication Date:
23 October 2007 (online)

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Significance

Erypoegin H, isolated from roots of the ornamental plant Erythrina poeppigiana, shows activity against Gram-positive bacteria including certain methicillin- and vancomycin-resistant strains. The key step of the synthesis is the formation of the benzofuran core in G by a PtCl2-catalyzed carboalkoxylation reaction. For more details on PtCl2-catalyzed intramolecular carboalkoxylation of alkynes, see: A. Fürstner, P. W. Davis J. Am. Chem. Soc. 2005, 127, 15024.