Facile Synthesis of Highly Functionalized Stable Ketenimines via a Three-Component Reaction

Abdolali Alizadeh; Sadegh Rostamnia

doi:10.1055/s-2007-990894

PAPER

Facile Synthesis of Highly Functionalized Stable Ketenimines via a Three-Component Reaction

Abdolali Alizadeh*, Sadegh Rostamnia
Department of Chemistry, Tarbiat Modares University, P.O. Box 14115-175, Tehran, Iran
Fax: +98(21)88006544; e-Mail: abdol_alizad@yahoo.com; e-Mail: aalizadeh@modares.ac.ir;

Abstract

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Abstract

It is shown that N-alkyl-substituted ketenimine derivatives can be efficiently prepared by the three-component coupling of electron-deficient alkynes, oximes, and isocyanides. The reaction is characterized by mild conditions, high selectivity, and tolerance to various functional groups. Yields are typically around 90%.

Key words

isocyanides - oximes - ketenimines - multicomponent reactions - zwitterions

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