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Synthesis 2007(22): 3553-3557  
DOI: 10.1055/s-2007-990811
PAPER
© Georg Thieme Verlag Stuttgart · New York

A Novel Short and Efficient Synthetic Route to the Antimalarial Agent FR900098 and Derivatives

Johann Perruchon, Regina Ortmann, Martin Schlitzer*
Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Marbacher Weg 6, 35032 Marburg, Germany
Fax: +49(6421)2825953; e-Mail: Schlitzer@staff.uni-marburg.de;
Further Information

Publication History

Received 23 July 2007
Publication Date:
25 September 2007 (online)

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Abstract

We report here a new operationally simple, economical, and environmentally friendly multicomponent approach for a one-pot synthesis of the antimalarial agent FR900098. The reaction allows the fast construction of the compound from simple and commercially available substrates and reagents and is also applicable to the synthesis of modified derivatives of FR900098.

Key words

drugs - multicomponent reactions - sulfonamides - sulfones - phosphonic acid

    References

  • 1 Schlitzer M. ChemMedChem  2007,  2:  944 
    CrossrefPubMedGoogle Scholar
  • 2a Borrmann S. Adegnika AA. Matsiegui P.-B. Issifou S. Schindler A. Mawilli-Mboumbe DP. Baranek T. Wiesner J. Jomaa H. Kremsner PG. J. Infect. Dis.  2004,  189:  901 
    CrossrefGoogle Scholar
  • 2b Borrmann S. Issifou S. Esser G. Adegnika AA. Ramharter M. Matsiegui P.-B. Oyakhirome S. Mawilli-Mboumbe DP. Missinou MA. Kun JFJ. Jomaa H. Kremsner PG. J. Infect. Dis.  2004,  190:  1534 
    CrossrefGoogle Scholar
  • 2c Borrmann S. Lundgren I. Oyakhirome S. Impouma B. Matsiegui P.-B. Adegnika AA. Issifou S. Kun JFJ. Hutchinson D. Wiesner J. Jomaa H. Kremsner PG. Antimicrob. Agents Chemother.  2006,  2713 
    CrossrefGoogle Scholar
  • 2d Oyakhirome S. Issifou S. Bongratz P. Barondi F. Ramharter M. Kun JF. Missinou MA. Lell B. Kremsner PG. Antimicrob. Agents Chemother.  2007,  1869 
    CrossrefGoogle Scholar
  • 3 Wiesner J. Borrmann S. Jomaa H. Parasitol. Res.  2003,  90:  S71 
    CrossrefGoogle Scholar