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Pharmacopsychiatry 2007; 40: S54-S61
DOI: 10.1055/s-2007-990302
Original Paper

© Georg Thieme Verlag KG Stuttgart · New York

Synchronous Oscillatory Activity and Working Memory in Schizophrenia

C. Haenschel 1 , 2 , P. J. Uhlhaas 1 , 2 , W. Singer 1 , 3
  • 1MPI for Brain Research, Frankfurt am Main
  • 2Department of Psychiatry, Johann Wolfgang Goethe Universität, Frankfurt am Main
  • 3Frankfurt Institute for Advanced Studies, Johann Wolfgang Goethe Universität, Frankfurt am Main
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Publication Date:
17 December 2007 (online)

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Abstract

Impairments in working memory (WM) are a core cognitive deficit in schizophrenia. Recent models of cognitive deficits have emphasized the potential role of neural synchrony as a pathophysiological mechanism underlying impaired WM performance in the disorder, suggesting that impaired maintenance as well as encoding of information may be related to deficits in sustaining precisely timed synchronized activity patterns. In the present paper, we will first summarise the role of synchronous oscillatory activity for working memory in normal brain functioning. Then we will examine the existing data on abnormal neural synchrony in schizophrenia, suggesting that neural synchrony may be critically involved in WM deficits. Neuropharmacological hypotheses will be discussed that have attempted to relate dysfunctional neural synchrony in schizophrenia to abnormalities in dopaminergic and GABAergic neurotransmission. Finally, computational neuropsychiatry may offer a framework for understanding neural synchrony within a complex dynamic nonlinear system and may provide new vistas for modelling WM deficits in schizophrenia.

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Correspondence

Dr. C. Haenschel

MPI for Brain Research

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Email: haenschel@mpih-frankfurt.mpg.de