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Dtsch Med Wochenschr 2007; 132(37): 1901-1904
DOI: 10.1055/s-2007-985615
DOI: 10.1055/s-2007-985615
Übersicht | Review article
Rheumatologie, Orthopädie© Georg Thieme Verlag KG Stuttgart · New York
Tragen Basistherapeutika in der Therapie rheumatischer Erkrankungen zu Wundheilungsstörungen bei? Sollten sie perioperativ abgesetzt werden?
Do DMARDs contibute to impaired healing after surgery? Should they be discontinued before surgery?Further Information
Publication History
eingereicht: 25.5.2007
akzeptiert: 26.7.2007
Publication Date:
07 September 2007 (online)

Schlüsselwörter
Basistherapeutika - DMARD - Methotrexat - Biologika - Immunsuppression
Key words
DMARDs - methotrexate - biologicals - immunosuppression
Literatur
- 1
Agnes M, Boerbooms T, Kerstens P JSM, van Loenhout J WA, Mulder J, van de Putte L BA.
Infections during low-dose methotrexate treatment in Rheumatoid Arthritis.
Semin Arthritis Rheum.
1995;
24
411-421
MissingFormLabel
- 2
Anstead G M.
Steroids, retinoids, and wound healing.
Adv Wound Care.
1998;
11
277-285
MissingFormLabel
- 3
Beck A, Salem K, Krischak G, Kinzl L, Bischoff M, Schmelz A.
Nichtsteroidale Antirheumatika (NSAR) in der perioperativen Phase in Traumatologie
und Orthopädie. Einfluss auf die Knochenheilung.
Oper Orthop Traumatol.
2005;
17
569-578
MissingFormLabel
- 4
Bridges S L, Lopez-Mendez A, Han K H, Tracy I C, Alarcon G S.
Should methotrexate be discontinued before elective orthopaedic surgery in patients
with rheumatoid arthritis?.
J Rheumatol.
1991;
18
984-988
MissingFormLabel
- 5
Carpenter M T, West S G, Vogelgesang S A, Casey Jones D E.
Postoperative joint infections in rheumatoid arthritis patients on methotrexate therapy.
Orthopedics.
1996;
19
207-210
MissingFormLabel
- 6
Den Broeder A A, Schraven T, De Jong E, De Rooij D, van den Hoogen F.
Infectious complications in elective surgery in RA patients in the anti-TNF era: a
retrospective study.
Ann Rheum Dis.
2005;
64
(Suppl III)
60
MissingFormLabel
- 7
Dixon W G, Lunt M, Watson K D, Hyrich K L.
Anti-TNF therapy and the risk of serious post-operative infection: results from the
BSR biologics register (BSRBR).
Ann Rheum Dis.
2007;
66
(Suppl II)
118
MissingFormLabel
- 8
Doran M F, Crowson C S, Pond G R, O’Fallon M, Gabriel S E.
Frequency of Infection in patients with rheumatoid arthritis compared with controls.
A population based study.
Arthritis Rheum.
2002;
46
2287-2293
MissingFormLabel
- 9
Doran M F, Crowson C S, Pond G R, O’Fallon W M, Gabriel S E.
Predictors of infection in rheumatoid arthritis.
Arthritis Rheum.
2002;
46
2294-2300
MissingFormLabel
- 10
Escalante A, Beardmore T D.
Risk factors for early wound complications after orthopedic surgery for rheumatoid
arthritis.
J Rheumatol.
1995;
22
1844-1851
MissingFormLabel
- 11
Fuerst M, Mohl H, Baumgartel K, Ruther W.
Leflunomid increases the risk of early healing complications in patients with rheumatoid
arthritis undergoing elective orthopaedic.
Rheumatol Int.
2006;
26
1138-1142
MissingFormLabel
- 12
Glück T, Kiefmann B, Grohmann M, Falk W, Straub R H, Schölmerich J.
Immune status and risk for infection in patients receiving chronic immunosuppressive
therapy.
J Rheumatol.
2005;
32
1473-1480
MissingFormLabel
- 13
Grennan D M, Gray J, Loudon J, Fear S.
Methotrexate and early postoperative complications in patients with rheumatoid arthritis
undergoing elective orthopaedic surgery.
Ann Rheum Dis.
2001;
60
214-217
MissingFormLabel
- 14
Haugeberg G, Strand A, Kvien T K, Kirwan J R.
Reduced loss of hand bone density with prednisolone in early rheumatoid arthritis:
results from a randomized placebo-controlled trial.
Arch Intern Med.
2005;
165
1293-1297
MissingFormLabel
- 15
Jain A, Witbreuk M, Ball C, Nanchahal J.
Influence of steroids and methotrexate on wound complications after elective rheumatoid
hand and wrist surgery.
J Hand Surg.
2002;
27
449-455
MissingFormLabel
- 16
Listing J, Strangfeld A, Kary S, Rau R, von Hinueber U, Stoyanova-Scholz M, Gromnica-Ihle E, Antoni C, Herzer P, Kekow J, Schneider M, Zink A.
Infections in patients with rheumatoid arthritis treated with biologic agents.
Arthritis Rheum.
2005;
52
3403-3412
MissingFormLabel
- 17
Matthews J LK, Martin L, Hu R.
Post operative complications in rheumatoid arthritis patients on anti-TNF therapies
undergoing orthopaedic procedures.
Ann Rheum Dis.
2006 ;
65
(Suppl II )
331
MissingFormLabel
- 18
Murata K, Yasuda T, Ito H, Yoshida M, Nakamura T.
Lack of increase in postoperative complications with low-dose methotrexate therapy
in patients with rheumatoid arthritis undergoing elective orthopedic surgery.
Mod Rheumatol.
2006;
16
14-19
MissingFormLabel
- 19
Perhala R S, Wilke W S, Clough J D, Segal A M.
Local infectious complications following large joint replacement in rheumatoid arthritis
patients treated with methotrexate versus those not treated with methotrexate.
Arthritis Rheum.
1991;
34
146-152
MissingFormLabel
- 20
Pieringer H, Stuby U, Biesenbach G.
patients with rheumatoid arthritis undergoing surgery: how should we deal with antirheumatic
treatment.
Semin Arthritis Rheum.
2007;
36
278-286
MissingFormLabel
- 21
Rehart S, Petak N.
Moderne rheumatische Basistherapie postoperativ. Patienten des rheumatischen Formenkreises
unter Therapie mit Methotrexat, Leflunomid bzw. TNF-alfa Blockern perioperativ.
Akt Rheumatol.
2007;
32
74-77
MissingFormLabel
- 22
Sany J, Anaya J M, Canovas F, Combe B, Jorgensen C, Saker S. et al .
Influence of methotrexate on the frequency of postoperative infectious complications
in patients with rheumatoid arthritis.
J Rheumatol.
1993;
20
1129-1132
MissingFormLabel
- 23
Shamberger R C, Devereux D F, Brennan M F.
The effect of chemotherapeutic agents on wound healing.
Int Adv Surg Oncol.
1981;
4
15-58
MissingFormLabel
- 24
Tanaka N, Sakahashi H, Sato E, Hirose K, Ishima T, Ishii S.
Examination of the risk of continuous leflunomide treatment on the incidence of infectious
complications after joint arthroplasty in patients with rheumatoid arthritis.
J Clin Rheumatol.
2003;
9
115-118
MissingFormLabel
- 25
Wendling D, Balblanc J C, Brousse A, Lohse A, Lehuede G, Garbuio P, Toussirot E, Auge B, Jacques D.
Surgery in patients receiving anti-tumour necrosis factor alpha treatment in rheumatoid
arthritis: an observational study on 50 surgical procedures.
Ann Rheum Dis.
2005;
64
1378-1379
MissingFormLabel
Priv.-Doz. Dr. Thomas Glück
Medizinische Abteilung, Kreisklinik Trostberg
Siegerthöhe 1
83308 Trostberg
Email: thomas.glueck@kreisklinik-trostberg.de