Catalytic Enantioselective Reductive Cyclization of Acetylenic Aldehydes via Hydrogenation

Abstract

The reductive cyclization of acetylenic aldehydes is accomplished via rhodium-catalyzed asymmetric hydrogenation. This process provides access to a wide variety of cyclic allylic alcohols in good yields and with high levels of asymmetric induction.

acetylenic aldehyde - allylic alcohol - hydrogenation - rhodium - reductive cyclization

References

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