Premature Infants: Analysis of Serum Phosphate during the First 4 Weeks of Life

Nahed El Hassan; Rita Ryan; Laroia Nirupama

doi:10.1055/s-2007-981431

American Journal of Perinatology, Inhaltsverzeichnis

Am J Perinatol 2007; 24(5): 327-330
DOI: 10.1055/s-2007-981431

Premature Infants: Analysis of Serum Phosphate during the First 4 Weeks of Life

Nahed El Hassan¹ , Rita Ryan² , Laroia Nirupama³

¹Department of Pediatrics, Division of Neonatology, College of Medicine, University of Arkansas Medical School, Arkansas Children's Hospital, Little Rock, Arkansas
²Department of Pediatrics, University of Rochester, Rochester, New York
³Division of Neonatology, State University of New York at Buffalo, Women & Children's Hospital of Buffalo, Buffalo, New York

Abstract

ABSTRACT

The purpose of this study was to establish phosphate norms for the first 4 weeks of life for neonates with birthweight (BW) 500 to 1500 g. The study group included 52 consecutively born neonates: group A (n = 24; BW 500 to 1000 g), and group B (n = 28; BW 1001 to 1500 g). Phosphate levels are reported daily (days 1 to 5), and then weekly until week 4. Except for the first 2 days of life, phosphate levels were statistically lower in group A versus group B. A prospective study is required to examine whether phosphate levels can be used as a marker of acuity in neonates and to examine the effect of phosphate repletion on metabolic functions.

KEYWORDS

Phosphorus - hypophosphatemia - low birthweight - premature

Volltext

Referenzen

REFERENCES

1 Bugg N C, Jones J A. Hypophosphataemia: pathophysiology, effects and management on the intensive care unit. Anaesthesia. 1998; 53 895-902
2 Knochel J P. The pathophysiology and clinical characteristics of severe hypophosphatemia. Arch Intern Med. 1977; 137 203-220
3 Brown G R, Greenwood J K. Drug and nutrition induced hypophosphatemia: mechanisms and relevance in the critically ill. Ann Pharmacother. 1994; 28 626-632
4 Haglin L, Burman L A, Nilsson M. High prevalence of hypophosphatemia amongst patients with infectious diseases. A retrospective study. J Intern Med. 1999; 246 45-52
5 Craddock P R, Yawata Y, VanSanten L, Gilberstadt S, Silvis S, Jacob H S. Acquired phagocyte dysfunction: a complication of the hypophosphatemia of parenteral hyperalimention. N Engl J Med. 1974; 290 1403-1407
6 Davis S V, Olichwier K K, Chakko S C. Reversible depression of myocardial performance in hypophosphatemia. Am J Med Sci. 1988; 295 183-187
7 Bollaert P E, Levy B, Nace L, Laterre P F, Larcan A. Hemodynamic and metabolic effects of rapid correction of hypophosphatemia in patients with septic shock. Chest. 1995; 107 1698-1701
8 Marick P E, Bedigian M K. Refeeding hypophosphatemia in critically ill patients in an intensive care unit: a prospective study. Arch Surg. 1996; 131 1043-1047
9 Lichtman M A, Miller D R, Cohen J, Waterhouse C. Reduced red cell glycolysis, 2, 3-diphosphoglycerate and adenosine triphophate concentration, and increased hemoglobin-oxygen affinity caused by hypophatemia. Ann Intern Med. 1971; 74 562-568
10 Zazzo J F, Troche G, Ruel P, Maintenant J. High incidence of hypophosphatemia in surgical intensive care patients: efficacy of phosphorus therapy on myocardial function. Intensive Care Med. 1995; 21 826-831
11 Barak V, Schwartz A, Kalickman I, Nisman B, Gurman G, Shoenfeld Y. Prevalence of hypophosphatemia in sepsis and infection: the role of cytokines. Am J Med. 1998; 104 40-47
12 Daily W H, Tonnesen A S, Allen S J. Hypophosphatemia: incidence, etiology, and prevention in the trauma patient. Crit Care Med. 1990; 18 1210-1214
13 Thomas J L, Reichelderfer T E. Premature infants: analysis of serum during the first seven weeks. Clin Chem. 1968; 14 272-280

Dr. Laroia Nirupama

Department of Pediatrics, University of Rochester

601 Elmwood Avenue, Box 651, Rochester, NY 14642