A Novel Synthesis of Spiro-2,5-dihydro-1,2-λ5-oxaphospholes Using a Three-Component Reaction

Abbas Ali Esmaeili; Saeid Amini; Asghar Bodaghi

doi:10.1055/s-2007-980357

Subscribe to RSS

Please copy the URL and add it into your RSS Feed Reader.

https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000083.xml

Share / Bookmark

Facebook X Linkedin Weibo

Download PDF

Synlett 2007(9): 1452-1454
DOI: 10.1055/s-2007-980357

LETTER

A Novel Synthesis of Spiro-2,5-dihydro-1,2-λ⁵-oxaphospholes Using a Three-Component Reaction

Abbas Ali Esmaeili*, Saeid Amini, Asghar Bodaghi
Department of Chemistry, University of Birjand, P. O. Box 97175-615, Birjand, Iran
Fax: +98(561)2230009; e-Mail: aa_esmaeili@yahoo.com;

Further Information

Publication History

Received 29 November 2006
Publication Date:
23 May 2007 (online)

Abstract
Full Text
References

Permissions and Reprints All articles of this category

Abstract

The zwitterionic intermediate generated from dialkyl acetylenedicarboxylate and triphenylphosphine on reaction with N-substituted isatins leads to new highly functionalized spiro-2,5-dihydro-1,2-oxaphospholes.

Key words

1,2-oxaphospholes - isatin - isopropylacetylenedicarboxylate - triphenylphosphine

References and Notes

1 Domling A. Ugi I. Angew. Chem. Int. Ed. 2000, 39: 3168

Crossref PubMed Google Scholar
2 Huisgen R. Proc. Chem. Soc., London 1961, 357

Google Scholar
3 Winterfeldt E. Angew. Chem., Int. Ed. Engl. 1967, 6: 423

Google Scholar
4 Johnson AW. Tebby JC. J. Chem. Soc. 1961, 2126

Crossref Google Scholar
5 Tebby JC. Wilson IF. Griffiths DV. J. Chem. Soc., Perkin Trans. 1 1979, 2133

Crossref Google Scholar
6 Ylides and Imines of Phosphorus Johnson AW. Wiley; New York: 1993.

Google Scholar
7 Phosphorus. An outline of chemistry, biochemistry and technology 5th ed.: Corbrige DEC. Elsevier; Amsterdam: 1995.

Google Scholar
8 Nicolaou KC. Harter MW. Gunzner JL. Nadin A. Liebigs Ann./Recl. 1997, 1283

Google Scholar
9 Cherkasov RA. Pudovik MA. Russ. Chem. Rev. (Engl. Transl.) 1994, 63: 1019

Crossref Google Scholar
10 Maryanoff BE. Reitz AB. Chem. Rev. 1989, 89: 863

Crossref Google Scholar
11 Phosphorous-Carbon Heterocyclic Chemistry: The Rise of a New Domain Mathey F. Pergamon; Amsterdam: 2001.

Google Scholar
12 Brassfield HA. Jacobson RA. Verkade JG. J. Am. Chem. Soc. 1975, 97: 4143

Crossref Google Scholar
13 Darrow JW. Druekhammer DG. J. Org. Chem. 1994, 59: 2976

Crossref Google Scholar
14 Rademacher TW. Parekh RB. Dwek RA. Ann. Rev. Biochem. 1988, 57: 785

Crossref Google Scholar
15 Morita I. Kunimoto K. Tsuda M. Tada SI. Kise M. Kimura K. Chem. Pharm. Bull. 1987, 35: 4144

Crossref Google Scholar
16 Hewitt DG. Newland GL. Aust. J. Chem. 1977, 30: 579

Google Scholar
17 Mader MM. Bartlett PA. Chem. Rev. 1997, 97: 1281

Crossref Google Scholar
18 Hudson HR. In The Chemistry of Organophosphorus Compounds: Primary, Secondary and Tertiary Phosphines and Heterocyclic Organophosphorus(III) Compounds Hantely FR. Wiley; New York: 1990. p.386-472

Google Scholar
19 Synthesis of Carbon-Phosphorus Bonds Engel R. CRC Press; Boca Raton: 1998.

Google Scholar
20 Organophosphorus Reagents in Organic Synthesis Cadogan JIG. Academic Press; New York: 1979.

Google Scholar
21 Yavari I. Alizadeh A. Anary-Abbasinejad M. Tetrahedron Lett. 2003, 44: 2877

Crossref Google Scholar
22 Esmaeili AA. Bodaghi A. Tetrahedron 2003, 59: 9169

Google Scholar
25 Naya S. Nitta M. J. Chem. Soc., Perkin Trans. 2 2002, 1017

Crossref Google Scholar
26 Nitta M. Naya S. J. Chem. Res., Synop. 1998, 522

Crossref Google Scholar
27 Takayasu T. Nitta M. J. Chem. Soc., Perkin Trans. 1 1997, 3255

Crossref Google Scholar
28 The Chemistry of Phosphorus Emsley J. Hall D. Harper and Row; London: 1976. p.82-83

Google Scholar
29 Osterberg AE. Org. Synth., Coll. Vol. I 1941, 271

Google Scholar

23

Compounds 1-methylisatin (3a), 5-bromo-1-methylisatin (3b), 1-ethylisatin (3c), 5-bromo-1-ethylisatin (3d), 1-benzylisatin (3e) and 1-benzyl-5-bromoisatin (3f) were prepared from alkyl benzensolfonates and the potassium isatin or potassium 5-bromoisatin by known methods.²⁹ Melting points were measured on an Electrothermal 9100 apparatus and are uncorrected. Elemental analyses for C, H and N were performed using a Heraeus CHN-O-Rapid analyzer. IR spectra were measured on a Perkin-Elmer 783 infrared spectrophotometer. ¹H, ¹³C and ³¹P NMR spectra were measured using a Bruker DRX-250 Avance spectrometer at 500, 125.7 and 202.5 MHz, respectively. Mass spectra were recorded on a Shimadzu GCMS-QP5050 mass spectrometer operating at an ionization potential of 70 eV.
Preparation of 1-(morpholinomethyl)isatin (3g): A slurry consisting of the isatin (5 mmol), THF (5 mL) and formalin (2 mL, 37%) was made. To this morpholine (5 mmol) was added dropwise, with cooling and stirring. The reaction mixture was allowed to stir at r.t. for 1 h and then it was warmed on a steam bath for 15 min. At the end of the period the contents were cooled and the product obtained was recrystallized from EtOAc-hexane. Mp 203-205 °C; IR (KBr): 1760, 1720 cm^-1; ¹H NMR (500 MHz, DMSO-d ₆): δ = 2.54 (t, J = 4.0 Hz, 4 H, -CH₂NCH₂-), 3.52 (t, J = 4.0 Hz, 4 H, -CH₂OCH₂-), 4.39 (s, 2 H, NCH₂N), 7.12 (t, J = 7.5 Hz, 1 H, CH_arom), 7.26 (d, J = 7.9 Hz, 1 H, CH_arom), 7.54 (d, J = 7.8 Hz, 1 H, CH_arom), 7.64 (t, J = 7.8 Hz, 1 H, CH_arom); ¹³C NMR (125 MHz, DMSO-d ₆): δ = 50.40 (-CH₂NCH₂-), 61.75 (NCH₂N), 65.98 (-CH₂OCH₂-), 111.94 (CH_arom), 117.52 (C_arom), 123.21 (CH_arom), 124.16 (CH_arom), 137.91 (CH_arom), 151.36 (C_arom), 158.90 (N-C=O), 183.10 (C=O); MS (EI, 70 eV): m/z (%) = 246 (2) [M⁺], 147 (2) [M⁺ - 99], 100 (100) [CH₂N(CH₂CH₂)₂].

24

General procedure for the synthesis of diisopropyl-2′,2′,2′-triphenyl-2-oxospiro[1-methylindole-3,5′-(2′,5′-dihydro-1′,2′-λ ⁵ -oxaphosphole)]-3′,4′-dicarboxylate (4a): To a magnetically stirred solution of N-methylisatin (2 mmol) and PPh₃ (2 mmol) in CH₂Cl₂ (3 mL) was added dropwise, DIAD (2 mmol) at r.t. over 10 min. After 5 h the crude reaction mixture was diluted with CH₂Cl₂ and passed through a short plug of silica gel. The solvent was removed under reduced pressure and the residue was purified by silica gel column chromatography to give a white powder; mp 177-178 °C; IR (KBr): 1720 (N-C=O) 1735, 1740 (2 CO₂ i-Pr), 1660 (C=C), 1610 (C=C_arom), 1430, 1107, 1009 (P-Ph), 1010 (P-O) cm^-1; ¹H NMR (500 MHz, CDCl₃): δ = 0.72 (d, J = 6.2 Hz, 3 H, CHMe ₂), 1.05 (d, J = 6.2Hz, 3 H, CHMe ₂), 1.09 (d, J = 6.0 Hz, 3 H, CHMe ₂), 1.10 (d, J = 6.0 Hz, 3 H, CHMe ₂), 3.11 (s, 3 H, N-Me), 4.53 (sept, J = 6.2 Hz, 1 H, OCHMe₂), 4.83 (sept, J = 6.2 Hz, 1 H, OCHMe₂), 6.14 (d, J = 7.3 Hz, 1 H, CH_arom), 6.68 (t, J = 7.5 Hz, 1 H, CH_arom), 6.70 (d, J = 7.7 Hz, 1 H,CH_arom), 7.15 (t, J = 7.6 Hz, 1 H, CH_arom), 7.30 (m, 9 H, CH_para and CH_meta of PPh₃), 7.70 (m, 6 H, CH_orthoof PPh₃); ¹³C NMR (125 MHz, CDCl₃): δ = 21.32 (Me), 21.47 (Me), 21.87 (Me), 21.90 (Me), 26.84 (N-Me), 69.57 (OCHMe₂), 70.07 (OCHMe₂), 79.09 (d, ² J _CP = 3.3 Hz, P-O-C_spiro), 108.30 (C_3a), 122.95 (C4), 124.37 (C5), 127.93 (d, ³ J _CP = 12.8 Hz, C_meta of PPh₃), 128.85 (C₇), 129.18 (C₆), 129.87 (C_para of PPh₃), 132.24 (d, ² J _CP = 9.9 Hz, C_ortho of PPh₃), 144.02 (d, ¹ J _CP = 103.1 Hz, C_ipsoof PPh₃) 147.05 (d,² J _CP = 30.1 Hz, C=C-P), 147.51 (d, ¹ J _CP = 50.9 Hz, C=C-P), 160.83 (d,² J _CP = 25 Hz, CO₂ i-Pr), 166.93 (d,³ J _CP = 19.2 Hz, CO₂ i-Pr), 174.53 (N-C=O); ³¹P NMR (202 MHz, CDCl₃); δ = -46.86; MS (EI, 70 eV): m/z (%) = 621 (5) [M⁺], 606 (1) [M⁺ - 15],578 (1) [M⁺ - i-Pr], 562 (2) [M⁺ - Oi-Pr]_, 544 (55) [M⁺ - C₆H₅], 447 (14) [M⁺+ 1 - 2CO₂ i-Pr], 277 (100) [Ph₃PO - H], 262 (40) [Ph₃P], 183 (52) [C₁₂H₈P], 152 (15) [C₁₂H₈], 108 (20) [C₆H₅P], 77 (30) [Ph]; Anal. Calcd for C₃₇ H₃₆ NO₆P: C, 71.49; H, 5.84; N, 2.25. Found: C, 71.00; H, 5.80; N, 2.30.