Semin Respir Crit Care Med 2007; 28(2): 222-242
DOI: 10.1055/s-2007-976494
Copyright © 2007 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Community Respiratory Virus Infections in Immunocompromised Patients: Hematopoietic Stem Cell and Solid Organ Transplant Recipients, and Individuals with Human Immunodeficiency Virus Infection

Yae-Jean Kim1 , 2 , Michael Boeckh1 , Janet A. Englund1 , 3
  • 1Division of Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, Washington
  • 2Department of Pediatrics, Samsung Medical Center, SungKyunKwan University School of Medicine, Seoul, Korea
  • 3Division of Infectious Diseases, Children’s Hospital and Regional Medical Center, Seattle, Washington
Further Information

Publication History

Publication Date:
25 April 2007 (online)

Preview

ABSTRACT

Infection is the leading cause of morbidity and mortality in immunocompromised patients such as hematopoietic/solid organ transplant recipients and individuals with human immunodeficiency virus. Community respiratory virus infections are increasingly recognized as a significant threat to these patients. This article reviews current information in the clinical field of community respiratory viruses, including several newly discovered respiratory viruses.

Respiratory syncytial virus, influenza viruses, parainfluenza viruses, and adenoviruses cause the most serious disease in immunocompromised hosts, but other respiratory viruses are becoming increasingly appreciated as a cause of both upper and lower respiratory tract disease. The clinical impact of these new viruses, including human metapneumovirus, non-SARS human coronaviruses, and human bocavirus, is not yet clear. Modern molecular technology has made the discovery of new viruses possible; the use of these new technologies in direct patient care is not yet standard but is becoming increasingly utilized. Clinicians should appreciate the potential for the development of antiviral resistance to influenza antivirals in immunocompromised patients.

REFERENCES

Janet A EnglundM.D. 

Children’s Hospital and Regional Medical Center

4800 Sand Point Way NE #W8851, Seattle, WA 98105

Email: janet.englund@seattlechildrens.org