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Synfacts 2007(5): 0459-0459  
DOI: 10.1055/s-2007-968391
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Ecteinascidin 597

Contributor(s): Philip Kocienski
J. Chen, X. Chen, M. Willot, J. Zhu*
Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, France
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Publication History

Publication Date:
24 April 2007 (online)

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Significance

Ecteinascidin 597 is a putative biogenetic precursor to ecteinascidin 743 which is in phase III clinical trials for the treatment of some cancers. A key step is the TMSBr-promoted macrocyclization of the thiol derived from D to form the 10-membered ring.