Chlorotrimethylsilane-Mediated Friedländer Synthesis of Polysubstituted Quinolines

Sergey V. Ryabukhin; Dmitriy M. Volochnyuk; Andrey S. Plaskon; Vasiliy S. Naumchik; Andrei A. Tolmachev

doi:10.1055/s-2007-966003

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Synthesis 2007(8): 1214-1224
DOI: 10.1055/s-2007-966003

PAPER

Chlorotrimethylsilane-Mediated Friedländer Synthesis of Polysubstituted Quinolines

Sergey V. Ryabukhin^a,b, Dmitriy M. Volochnyuk*^a,c, Andrey S. Plaskon^b, Vasiliy S. Naumchik^a, Andrei A. Tolmachev^b
^a Enamine Ltd., 23 A. Matrosova st., 01103 Kyiv, Ukraine
^b National Taras Shevchenko University, 62 Volodymyrska st., 01033 Kyiv-33, Ukraine
^c Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmanska 5, 02094 Kyiv-94, Ukraine
Fax: +380(44)5373253; e-Mail: D.Volochnyuk@enamine.net;

Further Information

Publication History

Received 12 December 2006
Publication Date:
28 March 2007 (online)

Abstract
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Abstract

New convenient conditions for the Friedländer synthesis of quinolines are described. Polysubstituted quinolines were readily prepared using chlorotrimethylsilane as a promoter and water-acceptor agent.

Key words

quinolines - annulation - o-amino aromatic carbonyls - chlorotrimethylsilane - parallel synthesis

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