Synthesis 2007(7): 1033-1037  
DOI: 10.1055/s-2007-965960
PAPER
© Georg Thieme Verlag Stuttgart · New York

Total Synthesis of Vulnibactin: A Natural Product Iron Chelator

Raymond J. Bergeron*, Neelam Bharti, Shailendra Singh
Department of Medicinal Chemistry, University of Florida, Gainesville, FL 32610-0485, USA
Fax: +1(352)3928406; e-Mail: rayb@ufl.edu;
Further Information

Publication History

Received 15 November 2006
Publication Date:
28 February 2007 (online)

Abstract

A short, high-yield, flexible synthesis is described for accessing vulnibactin and related siderophores, e.g., vibriobactin analogues and homologues. The spectral properties of the synthetic vulnibactin are identical with those reported for the natural product, thus confirming the proposed structure of vulnibactin.