Synthesis 2007(7): 1091-1095  
DOI: 10.1055/s-2007-965950
PAPER
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Advanced Intermediates of Lennoxamine Analogues

Prajakta S. Saranga, Arun A. Yadava, Prashant S. Patila, Urlam Murali Krishnab, Girish K. Trivedi*a, Manikrao M. Salunkhe*a
a Department of Chemistry, The Institute of Science, 15 Madam Cama Road, Mumbai 400032, India
Fax: +91(22)22816750; e-Mail: mmsalunkhe@hotmail.com; e-Mail: snehgkt@yahoo.com;
b Indian Institute of Technology, Bombay Powai, Mumbai 400076, India
Further Information

Publication History

Received 9 December 2006
Publication Date:
20 February 2007 (online)

Abstract

A simple and convenient method for synthesis of advanced isoindolone intermediates of lennoxamine and analogues is described in this paper. The intramolecular Diels-Alder reaction of furan is used as a key step in this synthesis.

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Crystallographic data for the structure in this paper has been deposited with the Cambridge Crystallographic Data Centre as supplementary publication No. CCDC 63347. Copies of the data can be obtained, free of charge, on application to CCDC, 12 Union Road, Cambridge CB2 1EZ, UK [fax: +44 (1223)336033 or E-mail: deposit@ccdc.cam.ac.uk]. Some selected crystallographic data: crystal system, space group: triclinic, P-1, bond lengths [Å] and angles [°]: N1-C8
1.322(2), N1-C9 1.457(3), N1-C10 1.458(3), O1-C(1) 1.213(2), O2-C1 1.311(3), O2-H2 1.03(4), O3-C8 1.247(2).