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DOI: 10.1055/s-2007-965950
Synthesis of Advanced Intermediates of Lennoxamine Analogues
Publication History
Publication Date:
20 February 2007 (online)
Abstract
A simple and convenient method for synthesis of advanced isoindolone intermediates of lennoxamine and analogues is described in this paper. The intramolecular Diels-Alder reaction of furan is used as a key step in this synthesis.
Key words
isoindolone - lennoxamine - Diels-Alder - imine - cycloadduct
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References
Crystallographic data for the structure in this paper has been deposited with the Cambridge Crystallographic Data Centre as supplementary publication No. CCDC 63347. Copies of the data can be obtained, free of charge, on application to CCDC, 12 Union Road, Cambridge CB2 1EZ, UK [fax: +44 (1223)336033 or E-mail: deposit@ccdc.cam.ac.uk]. Some selected crystallographic data: crystal system, space group: triclinic, P-1, bond lengths [Å] and angles [°]: N1-C8
1.322(2), N1-C9 1.457(3), N1-C10 1.458(3), O1-C(1) 1.213(2), O2-C1 1.311(3), O2-H2 1.03(4), O3-C8 1.247(2).