Synthesis of Thiophene Analogues of the Tacrine Series

David Thomae; Gilbert Kirsch; Pierre Seck

doi:10.1055/s-2007-965944

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Synthesis 2007(7): 1027-1032
DOI: 10.1055/s-2007-965944

PAPER

Synthesis of Thiophene Analogues of the Tacrine Series

David Thomae^a, Gilbert Kirsch*^a, Pierre Seck^b
^a Laboratoire d’Ingénierie Moléculaire et Biochimie Pharmacologique, Institut Jean Barriol, FR CNRS 2843, Université Paul Verlaine-Metz, 1 Boulevard Arago, 57070 Metz, France
Fax: +33(3)87325801; e-Mail: kirsch@univ-metz.fr;
^b Laboratoire de Chimie, Faculté des Sciences, de la Technologie et de la Communication Université du Luxembourg, 162a avenue de la Faïencerie, 1511 Luxembourg, Luxembourg

Further Information

Publication History

Received 29 November 2006
Publication Date:
20 February 2007 (online)

Abstract
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Abstract

3-Amino-2-cyanothiophenes condensed with cyclanones and afforded analogues of Velnacrine in two or three steps. Condensation under Friedländer’s conditions gave tacrine analogues in one step.

Key words

Alzheimer’s disease - tacrine analogues - Friedländer reaction - condensation - aminothiophene carbonitrile

References

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