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Klin Monbl Augenheilkd 2008; 225(1): 22-29
DOI: 10.1055/s-2007-963781
Übersicht

© Georg Thieme Verlag KG Stuttgart · New York

Keratoplastik nach HSV-Keratitis: Prävention und Therapie immunologischer Komplikationen

Keratoplasty in HSV Keratitis: Prevention and Therapy for Immunological ComplicationsS. Stanojlovic1 , S. Schlickeiser2, 3 , U. Pleyer3
  • 1Universitäts-Augenklinik, Klinisches Zentrum - Universität Belgrad
  • 2Institut für Medizinische Immunologie, Charité - Universitätsmedizin Berlin
  • 3Universitäts-Augenklinik, Charité - Universitätsmedizin Berlin
Further Information

Publication History

Eingegangen: 26.10.2007

Angenommen: 4.12.2007

Publication Date:
31 January 2008 (online)

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Zusammenfassung

Die Herpes-Virus-(HSV-)assoziierte Keratitis ist die häufigste Ursache postinfektiöser, persistierender Hornhauttrübung und stellt weiterhin eine wichtige Indikation zur Keratoplastik dar. In den letzten Jahren lässt sich ein Wandel in der Epidemiologie der Infektion und ihren Behandlungsmöglichkeiten beobachten. Ziel dieses Beitrages ist es, eine Übersicht zur aktuellen Entwicklung und insbesondere zu spezifischen Aspekten der Keratoplastik nach HSV-Keratitis zu bieten.

Abstract

Herpes simplex viral (HSV) keratitis is the leading infectious cause of secondary visual loss in the western world. Corneal stromal scaring is still an important indication for penetrating keratoplasty. Over the past decades the epidemiology of HSV infection as well as treatment strategies have changed. This review will address these recent findings with a focus on specific aspects of keratoplasty subsequent to HSV keratitis.

Schlüsselwörter

Kornea - Herpes-simplex-Virus - Keratitis - Keratoplastik - Transplantation

Key words

cornea - herpes simplex virus - keratitis - keratoplasty - transplantation

Literatur

  • 1 Akova Y A, Onat M, Duman S. Efficacy of low-dose and long-term oral acyclovir therapy after penetrating keratoplasty for herpes simplex heratitis.  Ocul Immunol Inflamm. 1999;  7 (1) 51-60
    Search in Google Scholar
  • 2 Al-Yousuf N, Mavrikakis I, Mavrikakis E. et al . Penetrating keratoplasty: indications over a 10 year period.  Br J Ophthalmol. 2004;  88 (8) 998-1001
    Search in Google Scholar
  • 3 Allison A C, Eugui E M. Mechanisms of action of mycophenolate mofetil in preventing acute and chronic allograft rejection.  Transplantation. 2005;  80 (Suppl 2) S181-S190
    Search in Google Scholar
  • 4 Beckingsale P, Mavrikakis I, Al-Yousuf N. et al . Penetrating keratoplasty: outcomes from a corneal unit compared to national data.  Br J Ophthalmol. 2006;  90 (6) 728-731
    Search in Google Scholar
  • 5 Bertelmann E, Reinhard T, Pleyer U. Stand der Immunprophylaxe und -therapie bei perforierender Keratoplastik. Eine Umfrage bei Mitgliedern der Sektion Kornea der DOG.  Ophthalmologe. 2003;  100 (12) 1031-1035
    Search in Google Scholar
  • 6 Beyer C F, Arens M Q, Hill G A. et al . Oral acyclovir reduces the incidence of recurrent herpes simplex keratitis in rabbits after penetrating keratoplasty.  Arch Ophthalmol. 1989;  107 (8) 1200-1205
    Search in Google Scholar
  • 7 Beyer C F, Hill J M, Reidy J J. et al . Corneal nerve disruption reactivates virus in rabbits latently infected with HSV-1.  Invest Ophthalmol Vis Sci. 1990;  31 (5) 925-932
    Search in Google Scholar
  • 8 Biswas P S, Rouse B T. Early events in HSV keratitis - setting the stage for a blinding disease.  Microbes Infect. 2005;  7 (4) 799-810
    Search in Google Scholar
  • 9 Biswas S, Suresh P, Bonshek R E. et al . Graft failure in human donor corneas due to transmission of herpes simplex virus.  Br J Ophthalmol. 2000;  84 (7) 701-705
    Search in Google Scholar
  • 10 Cleator G M, Klapper P E, Dennett C. et al . Corneal donor infection by herpes simplex virus: herpes simplex virus DNA in donor corneas.  Cornea. 1994;  13 (4) 294-304
    Search in Google Scholar
  • 11 Cobo L M, Coster D J, Rice N S. et al . Prognosis and management of corneal transplantation for herpetic keratitis.  Arch Ophthalmol. 1980;  98 (10) 1755-1759
    Search in Google Scholar
  • 12 Cockerham G C, Bijwaard K, Sheng Z M. et al . Primary graft failure: a clinicopathologic and molecular analysis.  Ophthalmology. 2000;  107 (11) 2083-2090; discussion 2090 - 2081
    Search in Google Scholar
  • 13 Cosar C B, Sridhar M S, Cohen E J. et al . Indications for penetrating keratoplasty and associated procedures, 1996 - 2000.  Cornea. 2002;  21 (2) 148-151
    Search in Google Scholar
  • 14 Cursiefen C, Rummelt C, Kuchle M. Immunohistochemical localization of vascular endothelial growth factor, transforming growth factor alpha, and transforming growth factor beta1 in human corneas with neovascularization.  Cornea. 2000;  19 (4) 526-533
    Search in Google Scholar
  • 15 Cursiefen C, Seitz B, Dana M R. et al . Angiogenese und Lymphangiogenese in der Hornhaut. Pathogenese, klinische Bedeutung und Therapieoptionen.  Ophthalmologe. 2003;  100 (4) 292-299
    Search in Google Scholar
  • 16 Dana M R, Qian Y, Hamrah P. Twenty-five-year panorama of corneal immunology: emerging concepts in the immunopathogenesis of microbial keratitis, peripheral ulcerative keratitis, and corneal transplant rejection.  Cornea. 2000;  19 (5) 625-643
    Search in Google Scholar
  • 17 Davidorf J M. Herpes simplex keratitis after LASIK.  J Refract Surg. 1998;  14 (6) 667
    Search in Google Scholar
  • 18 De Kesel R J, Koppen C, Ieven M. et al . Primary graft failure caused by herpes simplex virus type 1.  Cornea. 2001;  20 (2) 187-190
    Search in Google Scholar
  • 19 Dhaliwal D K, Barnhorst D A, Romanowski Jr E. et al . Efficient reactivation of latent herpes simplex virus type 1 infection by excimer laser keratectomy in the experimental rabbit ocular model.  Am J Ophthalmol. 1998;  125 (4) 488-492
    Search in Google Scholar
  • 20 Dhaliwal D K, Romanowski E G, Yates K A. et al . Valacyclovir inhibition of recovery of ocular herpes simplex virus type 1 after experimental reactivation by laser in situ keratomileusis.  J Cataract Refract Surg. 2001;  27 (8) 1288-1293
    Search in Google Scholar
  • 21 Dorrepaal S J, Cao K Y, Slomovic A R. Indications for penetrating keratoplasty in a tertiary referral centre in Canada, 1996 - 2004.  Can J Ophthalmol. 2007;  42 (2) 244-250
    Search in Google Scholar
  • 22 Ficker L A, Kirkness C M, Rice N S. et al . The changing management and improved prognosis for corneal grafting in herpes simplex keratitis.  Ophthalmology. 1989;  96 (11) 1587-1596
    Search in Google Scholar
  • 23 Flowers C W, Chanq K Y, McLeod S D. et al . Changing indications for penetrating keratoplasty, 1989 - 1993.  Cornea. 1995;  14 (6) 583-588
    Search in Google Scholar
  • 24 Gong N, Pleyer U, Vogt K. et al . Local overexpression of nerve growth factor in rat corneal transplants improves allograft survival.  Invest Ophthalmol Vis Sci. 2007;  48 (3) 1043-1052
    Search in Google Scholar
  • 25 Gore S M, Bird A G, Ross A J. Prison rites: starting to inject inside.  Bmj. 1995;  311 (7013) 1135-1136
    Search in Google Scholar
  • 26 Harooni H, Reddy V, Root T. et al . Bevacizumab for graft rejection.  Ophthalmology. 2007;  114 (10) 1950
    Search in Google Scholar
  • 27 Heiligenhaus A, Steuhl K P. Treatment of HSV-1 stromal keratitis with topical cyclosporin A: a pilot study.  Graefes Arch Clin Exp Ophthalmol. 1999;  237 (5) 435-438
    Search in Google Scholar
  • 28 Hendricks R L, Janowicz M, Tumpey T M. Critical role of corneal Langerhans cells in the CD 4- but not CD 8-mediated immunopathology in herpes simplex virus-1-infected mouse corneas.  J Immunol. 1992;  148 (8) 2522-2529
    Search in Google Scholar
  • 29 Hosseini H, Khalili M R. Therapeutic potential of bevacizumab (Avastin) in herpetic stromal keratitis (HSK).  Med Hypotheses. 2007;  69 (3) 568-570
    Search in Google Scholar
  • 30 Jarade E F, Tabbara K F. Laser in situ keratomileusis in eyes with inactive herpetic keratitis.  Am J Ophthalmol. 2001;  132 (5) 779-780
    Search in Google Scholar
  • 31 Kaye S, Choudhary A. Herpes simplex keratitis.  Prog Retin Eye Res. 2006;  25 (4) 355-380
    Search in Google Scholar
  • 32 Kaye S B, Baker K, Bonshek R. et al . Human herpesviruses in the cornea.  Br J Ophthalmol. 2000;  84 (6) 563-571
    Search in Google Scholar
  • 33 Kersten A, Sundmacher R, Reinhard T. Postoperative Komplikationen nach perforierender Keratoplastik in Herpesaugen: Differentialdiagnose, Therapie und prognostische Bedeutung.  Ophthalmologe. 1997;  94 (12) 889-896
    Search in Google Scholar
  • 34 Kinghorn G R. Epidemiology of genital herpes.  J Int Med Res. 1994;  22 (Suppl 1) 14A-23A
    Search in Google Scholar
  • 35 Klebe S, Sykes P J, Coster D J. et al . Prolongation of sheep corneal allograft survival by ex vivo transfer of the gene encoding interleukin-10.  Transplantation. 2001;  71 (9) 1214-1220
    Search in Google Scholar
  • 36 Larkin D F, Oral H B, Ring C J. et al . Adenovirus-mediated gene delivery to the corneal endothelium.  Transplantation. 1996;  61 (3) 363-370
    Search in Google Scholar
  • 37 Legeais J M, Parc C, d’Hermies F. et al . Nineteen years of penetrating keratoplasty in the Hotel-Dieu Hospital in Paris.  Cornea. 2001;  20 (6) 603-606
    Search in Google Scholar
  • 38 Lepisto A J, Frank G M, Hendricks R L. How herpes simplex virus type 1 rescinds corneal privilege.  Chem Immunol Allergy. 2007;  92 203-212
    Search in Google Scholar
  • 39 Levy J, Lapid-Gortzak R, Klemperer I. et al . Herpes simplex virus keratitis after laser in situ keratomileusis.  J Refract Surg. 2005;  21 (4) 400-402
    Search in Google Scholar
  • 40 Liekfeld A, Jaeckel C, Pleyer U. et al . Kammerwasseranalyse bei Keratoplastikpatienten mit Keratitiden. Erste Resultate.  Ophthalmologe. 2001;  98 (5) 456-459
    Search in Google Scholar
  • 41 Liesegang T J. Herpes simplex virus epidemiology and ocular importance.  Cornea. 2001;  20 (1) 1-13
    Search in Google Scholar
  • 42 Liu E, Slomovic A R. Indications for penetrating keratoplasty in Canada, 1986 - 1995.  Cornea. 1997;  16 (4) 414-419
    Search in Google Scholar
  • 43 Liu Y, Hamrah P, Zhang Q. et al . Draining lymph nodes of corneal transplant hosts exhibit evidence for donor major histocompatibility complex (MHC) class II-positive dendritic cells derived from MHC class II-negative grafts.  J Exp Med. 2002;  195 (2) 259-268
    Search in Google Scholar
  • 44 Lomholt J A, Baggesen K, Ehlers N. Recurrence and rejection rates following corneal transplantation for herpes simplex keratitis.  Acta Ophthalmol Scand. 1995;  73 (1) 29-32
    Search in Google Scholar
  • 45 Mayer K, Reinhard T, Reis A. et al . Synergistic antiherpetic effect of acyclovir and mycophenolate mofetil following keratoplasty in patients with herpetic eye disease: first results of a randomised pilot study.  Graefes Arch Clin Exp Ophthalmol. 2003;  241 (12) 1051-1054
    Search in Google Scholar
  • 46 Metcalf J F, Hamilton D S, Reichert R W. Herpetic keratitis in athymic (nude) mice.  Infect Immun. 1979;  26 (3) 1164-1171
    Search in Google Scholar
  • 47 Nicholls S M, Shimeld C, Easty D L. et al . Recurrent herpes simplex after corneal transplantation in rats.  Invest Ophthalmol Vis Sci. 1996;  37 (2) 425-435
    Search in Google Scholar
  • 48 Patel N P, Kim T, Rapuano C J. et al . Indications for and outcomes of repeat penetrating keratoplasty, 1989 - 1995.  Ophthalmology. 2000;  107 (4) 719-724
    Search in Google Scholar
  • 49 Pepose J S, Keadle T L, Morrison L A. Ocular herpes simplex: changing epidemiology, emerging disease patterns, and the potential of vaccine prevention and therapy.  Am J Ophthalmol. 2006;  141 (3) 547-557
    Search in Google Scholar
  • 50 Philipp W, Speicher L, Humpel C. Expression of vascular endothelial growth factor and its receptors in inflamed and vascularized human corneas.  Invest Ophthalmol Vis Sci. 2000;  41 (9) 2514-2522
    Search in Google Scholar
  • 51 Rao S N. Treatment of herpes simplex virus stromal keratitis unresponsive to topical prednisolone 1 % with topical cyclosporine 0.05 %.  Am J Ophthalmol. 2006;  141 (4) 771-772
    Search in Google Scholar
  • 52 Rasquin F, Demols P, Schrooyen M. et al . Primo-infection herpetique post-keratoplastie transfixiante.  Bull Soc Belge Ophtalmol. 1998;  268 79-85
    Search in Google Scholar
  • 53 Reis A, Reinhard T, Sundmacher R. et al . Mycophenolatmofetil (CellCept) bei okularen immunologischen Störungen. Literaturübersicht mit 3 Kasuistiken.  Klin Monatsbl Augenheilkd. 1998;  213 (5) 257-261
    Search in Google Scholar
  • 54 Reis A, Reinhard T, Voiculescu A. et al . Hochaktive antivirale und immunsuppressive Kombinationstherapie mit Acyclovir und Mycophenolatmofetil nach Keratoplastik bei herpetischer Grunderkrankung.  Klin Monatsbl Augenheilkd. 2001;  218 (3) 183-186
    Search in Google Scholar
  • 55 Remeijer L, Doornenbal P, Geerards A J. et al . Newly acquired herpes simplex virus keratitis after penetrating keratoplasty.  Ophthalmology. 1997;  104 (4) 648-652
    Search in Google Scholar
  • 56 Remeijer L, Maertzdorf J, Buitenwerf J. et al . Corneal herpes simplex virus type 1 superinfection in patients with recrudescent herpetic keratitis.  Invest Ophthalmol Vis Sci. 2002;  43 (2) 358-363
    Search in Google Scholar
  • 57 Remeijer L, Maertzdorf J, Doornenbal P. et al . Herpes simplex virus 1 transmission through corneal transplantation.  Lancet. 2001;  357 (9254) 442
    Search in Google Scholar
  • 58 Rezende R A, Uchoa U B, Raber I M. et al . New onset of herpes simplex virus epithelial keratitis after penetrating keratoplasty.  Am J Ophthalmol. 2004;  137 (3) 415-419
    Search in Google Scholar
  • 59 Ritter T, Gong N, Pleyer U. Is ex vivo adenovirus mediated gene transfer a therapeutic option for the treatment of corneal diseases?.  Br J Ophthalmol. 2005;  89 (6) 648-649
    Search in Google Scholar
  • 60 Robert P Y, Adenis J P, Denis F. et al . Herpes simplex virus DNA in corneal transplants: prospective study of 38 recipients.  J Med Virol. 2003;  71 (1) 69-74
    Search in Google Scholar
  • 61 Robert P Y, Adenis J P, Pleyer U. Wie „sicher” ist das Hornhauttransplantat? - Ein Beitrag zum Risiko der HSV-Transmission durch Hornhauttransplantation.  Klin Monatsbl Augenheilkd. 2005;  222 (11) 870-873
    Search in Google Scholar
  • 62 Robert P Y, Liekfeld A, Metzner S. et al . Specific antibody production in herpes keratitis: intraocular inflammation and corneal neovascularisation as predicting factors.  Graefes Arch Clin Exp Ophthalmol. 2006;  244 (2) 210-215
    Search in Google Scholar
  • 63 Sundmacher R. Die Pathophysiologie der Herpes-simplex-Rezidive.  Klin Monatsbl Augenheilkd. 1977;  170 (4) 613-621
    Search in Google Scholar
  • 64 Sundmacher R, Neumann-Haefelin D. Keratitis metaherpetica - Klinische und virologische Befunde.  Klin Monatsbl Augenheilkd. 1976;  169 (6) 728-737
    Search in Google Scholar
  • 65 Sundmacher R, Stefansson A, Mackensen G. Verlaufsbeobachtungen nach Keratoplastik.  Fortschr Ophthalmol. 1983;  80 (3) 224-227
    Search in Google Scholar
  • 66 Tambasco F P, Cohen E J, Nguyen L H. et al . Oral acyclovir after penetrating keratoplasty for herpes simplex keratitis.  Arch Ophthalmol. 1999;  117 (4) 445-449
    Search in Google Scholar
  • 67 Rooij van J, Rijneveld W J, Remeijer L. et al . Effect of oral acyclovir after penetrating keratoplasty for herpetic keratitis: a placebo-controlled multicenter trial.  Ophthalmology. 2003;  110 (10) 1916-1919; discussion 1919
    Search in Google Scholar
  • 68 Volker-Dieben H J, Claas F H, Schreuder G M. et al . Beneficial effect of HLA-DR matching on the survival of corneal allografts.  Transplantation. 2000;  70 (4) 640-648
    Search in Google Scholar
  • 69 Volker-Dieben H J, Kok-Alphen C C, D’Amaro van J. et al . The effect of prospective HLA-A and -B matching in 288 penetrating keratoplasties for herpes simplex keratitis.  Acta Ophthalmol (Copenh). 1984;  62 (4) 513-523
    Search in Google Scholar
  • 70 Weiss H. Epidemiology of herpes simplex virus type 2 infection in the developing world.  Herpes. 2004;  11 (Suppl 1) 24A-35A
    Search in Google Scholar
  • 71 Xu F, Schillinger J A, Sternberg M R. et al . Seroprevalence and coinfection with herpes simplex virus type 1 and type 2 in the United States, 1988 - 1994.  J Infect Dis. 2002;  185 (8) 1019-1024
    Search in Google Scholar
  • 72 Yahalom C, Mechoulam H, Solomon A. et al . Forty years of changing indications in penetrating keratoplasty in Israel.  Cornea. 2005;  24 (3) 256-258
    Search in Google Scholar
  • 73 Zheng M, Schwarz M A, Lee S. et al . Control of stromal keratitis by inhibition of neovascularization.  Am J Pathol. 2001;  159 (3) 1021-1029
    Search in Google Scholar
  • 74 Zheng X, Loutsch J M, Shimomura Y. et al . Reactivation of herpes virus after lamellar keratoplasty.  Jpn J Ophthalmol. 1999;  43 (4) 257-261
    Search in Google Scholar

Prof. Uwe Pleyer

Universitäts-Augenklinik, Charité Campus Virchow-Klinik

Augustenburger Platz 1

13353 Berlin

Phone: ++ 49/30/4 50 55 41 31

Fax: ++ 49/30/4 50 55 49 00

Email: Uwe.pleyer@charite.de