ABSTRACT
In this study, a 2 mm internal diameter (i.d.) polytetrafluoroethylene (PTFE) microprosthesis
was used in the venous system of the rat, to determine whether or not it could serve
as an acceptable microvenous substitute. Forty Long-Evans rats were divided into four
groups: Group 1-10 rats with autotrans-plant of an inferior vena cava segment; Group
2-10 rats with a segment substitution of the inferior vena cava by a 2 mm i.d. PFTE
microprosthesis; Group 3-10 rats with a laterolateral portacaval shunt; and Group
4-10 rats with a portacaval shunt and interposition of a 2 mm i.d. PTFE microprosthesis
(new model). The rats were sacrificed at different time intervals up to 100 days,
with cavography (femoral access) in Groups 1 and 2 and spleenoportography (direct
puncture of the spleen) in Groups 3 and 4, before sacrifice.
In Group 1, a 100 percent patency was observed at a mean of 49 days; in Group 2, a
70 percent patency with a 30 percent stenosis at a mean of 39.4 days (p < 0.05); in Group 3, a 100 percent patency at a mean of 42.5 days; and in Group 4,
a 30 percent patency at a mean of 38.4 days (p < 0.01).
Results showed that the 2 mm i.d. PTFE microprosthesis placed in the venous system
of the rat is not an efficacious procedure, and that the search for better microvenous
substitutes should focus on those of biologic origin.
