ABSTRACT
Leukocyte adhesion and emigration are controlled by soluble mediators and effected
by various adhesion molecules. Currently, three major families of adhesion receptors
are known to contribute to this process: integrins, vascular selectins, and immunoglobulin-like
receptors. These adhesion systems are not additive and mutually replaceable, but appear
to constitute a cascade of events. Leukocyte margination is followed by rolling, firm
adhesion, emigration, and migration in the interstitial space. In addition, biomechanical
parameters like leukocyte deformability and shear stress exerted by the flowing blood
modulate the efficacy of adhesive interaction. This article briefly reviews the molecular
nature, biologic regulation, and physiologic function of pertinent adhesion receptors.
