ABSTRACT
The effects of both isograft transplantation and immobilization by sciatic and femoral
neurotomy on bone changes in the tibia were studied in adult rats. The effects of
the administration of (Asu1,7)-eel calcitonin on bone changes in the tibia induced by the same procedures were
also examined. Bone volume, dry weight, ash weight, calcium weight, and strength were
measured. Bone density of the tibia in the isograft transplantation group was less
than that of the immobilization group, indicating that the osteoporosis induced by
sciatic and femoral neurotomy and isograft transplantation differed. (Asu1,7)-eel calcitonin increased tibia bone density, ash per volume, calcium per volume,
and phosphorus per volume, when subjected to isograft transplantation but not in sciatic
neurotomy. Bone atrophy induced by immobilization through sciatic and femoral neurotomy
and that induced by isograft transplantation were thus shown to differ.
