Application of 2,2,2-Trichloroethoxycarbonyl Protection to Aminoacridines

Abstract

The 2,2,2-trichloroethoxycarbonyl (Troc) group has been successfully used as a protecting group for aminoacridines. Unlike aliphatic amines, deprotection of these aromatic amines yields significant amounts (12-29%) of stable 2,2-dichloroethoxycarbonyl (Dioc) by-products. Formation of bis-carbamates, through the introduction of butoxycarbonyl (Boc) moieties as temporary protecting groups, efficiently solves this problem.

Key words

fused-ring systems - heterocycles - amino protecting group - carbamate

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