A Simple Protocol for the Generation of Methyl(trifluoromethyl)dioxirane

Rossella Mello; María Elena González-Núñez; Gregorio Asensio

doi:10.1055/s-2006-958422

LETTER

A Simple Protocol for the Generation of Methyl(trifluoromethyl)dioxirane

Rossella Mello*, María Elena González-Núñez, Gregorio Asensio
Departamento de Química Orgánica, Universidad de Valencia, Avda. V. Andrés Estellés s/n, 46100-Burjassot (Valencia), Spain
Fax: +34(96)3544939; e-Mail: rossella.mello@uv.es;

Abstract

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Abstract

Methyl(trifluoromethyl)dioxirane, generated from an aqueous solution of 1,1,1-trifluoroacetone hydrate, sodium bicarbonate and peroxomonosulfate, is removed from the reaction mixture by the evolved gases and applied to the oxidation of substrates placed in a second reaction zone. The method is simple and robust, and allows for the application of methyl(trifluoromethyl)dioxirane in oxidation reactions on a preparative scale.

Key words

dioxiranes - methyl(trifluoromethyl)dioxirane - oxidation - oxygenation - synthesis

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References

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