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Semin Respir Crit Care Med 2006; 27(6): 589-599
DOI: 10.1055/s-2006-957331
DOI: 10.1055/s-2006-957331
Inflammation and Angiogenesis in Fibrotic Lung Disease
Further Information
Publication History
Publication Date:
29 December 2006 (online)
ABSTRACT
The pathogenesis of pulmonary fibrosis is poorly understood. Although inflammation has been presumed to have an important role in the development of fibrosis this has been questioned recently, particularly with regard to idiopathic pulmonary fibrosis (IPF). It is, however, increasingly recognized that the polarization of the inflammatory response toward a type 2 phenotype supports fibroproliferation. Increased attention has been on the role of noninflammatory structural cells such as the fibroblast, myofibroblast, epithelial cell, and endothelial cells. Furthermore, the origin of these cells appears to be multifactorial and includes resident cells, bone marrow-derived cells, and epithelial to mesenchymal transition. Increasing evidence supports the presence of vascular remodeling in fibrotic lung disease, although the precise role in the pathogenesis of fibrosis remains to be determined. Therefore, the pathogenesis of pulmonary fibrosis is complex and involves the interaction of multiple cell types and compartments within the lung.
KEYWORDS
Idiopathic pulmonary fibrosis - angiogenesis - fibrosis - fibroblasts - chemokines
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Michael P KeaneM.D.
UCLA, Department of Medicine, Division of Pulmonary and Critical Care Medicine
900 Veteran Ave., 14-154 Warren Hall, Los Angeles, CA 90095-1922
Email: mpkeane@mednet.ucla.edu