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Dtsch Med Wochenschr 2006; 131(46): 2601-2604
DOI: 10.1055/s-2006-956256
DOI: 10.1055/s-2006-956256
Aktuelle Diagnostik & Therapie | Review article
Hypertensiologie© Georg Thieme Verlag KG Stuttgart · New York
Monogenetische Hypertonie
Monogenic hypertensionFurther Information
Publication History
eingereicht: 7.10.2006
akzeptiert: 26.10.2006
Publication Date:
09 November 2006 (online)

Schlüsselwörter
monogenetische Hypertonie - Liddle-Syndrom - Gordon-Syndrom - Hyperaldosteronismus - Mineralokortikoidexzess
Key words
monogenic hypertension - Liddle syndrome - Gordon syndrome - hyperaldosteronism - mineralocorticoid excess
Literatur
- 1
Ferrari P, Lovati E, Frey F J.
The role of the 11beta-hydroxysteroid dehydrogenase type 2 in human hypertension.
J Hypertens.
2000;
18
241-248
MissingFormLabel
- 2
Geller D S, Farhi A, Pinkerton N, Fradley M, Moritz M, Spitzer A, Meinke G, Tsai F T, Sigler P B, Lifton R P.
Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy.
Science.
2000;
289
119-123
MissingFormLabel
- 3
Hansson J H, Schild L, Lu Y, Wilson T A, Gautschi I, Shimkets R, Nelson-Williams C, Rossier B C, Lifton R P.
A De novo missense mutation of the beta subunit of the epithelial sodium channel causes
hypertension and Liddle syndrome, identifying a proline-rich segment critical for
regulation of channel activity.
Proc Natl Acad Sci U S A.
1995;
92
11495-11499
MissingFormLabel
- 4
Kahle K T, Wilson F H, Leng Q, Lalioti M D, O’Connell A D, Dong K, Rapson A K, MacGregor G G, Giebisch G, Hebert S C, Lifton R P.
WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion.
Nat Genet.
2003;
35
372-376
MissingFormLabel
- 5
Lalioti M D, Zhang J, Volkman H M, Kahle K T, Hoffmann K E, Toka H R, Nelson-Williams C, Ellison D H, Flavell R, Booth C J, Lu Y, Geller D S, Lifton R P.
Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and
activity of the distal convoluted tubule.
Nat Genet.
2006;
38
1124-1132
MissingFormLabel
- 6
Lifton R P, Gharavi A G, Geller D S.
Molecular mechanisms of human hypertension.
Cell.
2001;
104
545-556
MissingFormLabel
- 7
Lifton R P, Dluhy R G, Powers M, Rich G M, Cook S, Ulick S, Lalouel J M.
A chimaeric 11 beta-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable
aldosteronism and human hypertension.
Nature.
1992;
355
262-265
MissingFormLabel
- 8
Luft F C.
Monogenic hypertension: lessons from the genome.
Kidney Int.
2001;
60
381-390
MissingFormLabel
- 9
Mune T, Rogerson F M, Nikkila H, Agarwal A K, White P C.
Human hypertension caused by mutations in the kidney isozyme of 11 beta-hydroxysteroid
dehydrogenase.
Nat Genet.
1995;
10
394-399
MissingFormLabel
- 10
Rafestin-Oblin M E, Souque A, Bocchi B, Pinon G, Fagart J, Vandewalle A.
The severe form of hypertension caused by the activating S810L mutation in the mineralocorticoid
receptor is cortisone related.
Endocrinology.
2003;
144
528-533
MissingFormLabel
- 11
Toka H R, Luft F C.
Monogenic forms of human hypertension.
Semin Nephrol.
2002;
22
81-88
MissingFormLabel
- 12
Wilson F H, Disse-Nicodeme S, Choate K A, Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford D V, Lipkin G W, Achard J M, Feely M P, Dussol B, Berland Y, Unwin R J, Mayan H, Simon D B, Farfel Z, Jeunemaitre X, Lifton R P.
Human hypertension caused by mutations in WNK kinases.
Science.
2001;
293
1107-1112
MissingFormLabel
Prof. Dr. J. Hoyer
Klinik für Innere Medizin und Nephrologie Universitätsklinikum Gießen und Marburg
GmbH Standort Marburg
Baldingerstraße
35033 Marburg
Phone: 06421 2866480
Fax: 06421 2866365
Email: hoyer@med.uni-marburg.de