Recently, tricyclic antidepressants (TCAs) have been used mainly for treatment-resistant depression (TRD) because of their significant side effects [5]. We report a patient whose prolonged depressive symptoms dramatically improved after the cessation of TCAs. TCAs may cause deterioration of depressive symptoms due to their neurotoxicity.
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Keizo Yoshida, M.D., Ph. D.
Department of Psychiatry
Nagoya University Graduate School of Medicine
65 Tsurumai-cho
Showa-ku
Nagoya
Aichi 466-8550
Japan
Phone: +81 52 744 2283
Fax: +81 52 744 2293
Email: cxw01076@nifty.com
