A Convenient Synthesis of Aryl Ferrocenylethynyl Ketones and 2-Ferrocenyl-4H-chromen-4-ones via Palladium-Catalyzed Carbonylation Coupling

Wenbing Ma; Xiaolong Li; Jingmu Yang; Zenglu Liu; Baohua Chen; Xinfu Pan

doi:10.1055/s-2006-942481

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A Convenient Synthesis of Aryl Ferrocenylethynyl Ketones and 2-Ferrocenyl-4H-chromen-4-ones via Palladium-Catalyzed Carbonylation Coupling

Wenbing Ma^a, Xiaolong Li^a, Jingmu Yang^b, Zenglu Liu^c, Baohua Chen*^a, Xinfu Pan^a
^a State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China
Fax: +86(931)8912582; e-Mail: chbh@lzu.edu.cn;
^b State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P. R. of China
^c Pharmacy College of Shanghai Jiao Tong University, Shanghai 200030, P. R. of China

Abstract

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Abstract

The palladium-catalyzed carbonylation coupling reaction of ethynylferrocene with aryl iodides under an atmosphere of carbon monoxide is a convenient, effective, and versatile method for the synthesis of aryl ferrocenyethynyl ketones. Likewise, the palladium-catalyzed carbonylation coupling-annulation reaction of ethynylferrocene with substituted 2-iodophenol gives 2-ferrocenyl-4H-chromen-4-ones. The reactions were performed in short time and gave the products in good yield.

Key words

carbonylation - aryl ferrocenylethynyl ketones - 2-ferrocenyl-4H-chromen-4-ones - palladium catalysis - annulation

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References

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