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Synthesis 2006(12): 1940-1942
DOI: 10.1055/s-2006-942359
DOI: 10.1055/s-2006-942359
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York
A Practical Regiospecific Synthesis of 9-Nitrocamptothecin
Further Information
Received
22 December 2005
Publication Date:
05 May 2006 (online)
Publication History
Publication Date:
05 May 2006 (online)
Abstract
9-Nitrocamptothecin has shown potent antitumor activity against many types of human cancers. A practical scale-up procedure for this compound is reported by selective reduction of corresponding sulfonate.
Key words
9-nitrocamptothecin - nitration - reduction of sulfonate
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