Acute Onset of Severe Hemolysis, Elevated Liver Enzymes, and Low Platelet Count Syndrome in a Patient with a Partial Hydatidiform Mole at 17 Weeks Gestation

ABSTRACT

Preeclampsia is uncommon prior to 24 weeks gestation and has been associated with partial and complete hydatidiform moles. We present an unusual case in which a patient was diagnosed with preeclampsia at 17 weeks gestation. Ultrasound findings were consistent with a partial hydatidiform mole. Within 24 hours of the onset of symptoms, the patient developed severe hemolysis, elevated liver enzymes, and low platelet count syndrome, with a platelet count of 20 × 10⁹ cells/L. Termination of pregnancy was performed with rapid resolution of signs, symptoms, and laboratory abnormalities. Triploid 69,XXY was confirmed at karyotype analysis. This case demonstrates the acuteness in which life-threatening maternal conditions can arise with this uncommon complication of pregnancy, and the importance of correct identification of the characteristic ultrasonographic findings associated with a partial hydatidiform mole.

KEYWORDS

Partial hydatidiform mole - HELLP syndrome - midtrimester preeclampsia - triploidy 69 - XXY - ultrasound - paternal genotype

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