A Short and Simple Synthesis of 1-Deoxynojirimycin Derivatives from d-Glucose

Ashim Roy; Basudeb Achari; Sukhendu B. Mandal

doi:10.1055/s-2006-926369

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A Short and Simple Synthesis of 1-Deoxynojirimycin Derivatives from d-Glucose

Ashim Roy, Basudeb Achari, Sukhendu B. Mandal*
Division of Medicinal Chemistry, Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Jadavpur, Kolkata 700032, India
Fax: +91(33)24735197; e-Mail: sbmandal@iicb.res.in;

Abstract

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Abstract

Insertion of an amino functionality at C-5 of d-glucose with inversion of configuration, followed by imine formation with the latent aldehyde at C-1 and concomitant reduction furnished the 1-deoxynojirimycin skeleton.

Key words

1-deoxynojirimycin - d-glucose - hydrogenolysis - cyclization

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References

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