Abstract
We tested whether the G894T and T-786C NOS3 polymorphisms were associated with exercise
cardiovascular (CV) hemodynamics in sedentary, physically active, and endurance-trained
postmenopausal women. CV hemodynamic parameters including heart rate (HR), systolic
(SBP) and diastolic (DBP) blood pressures and cardiac output (Q), as determined by
acetylene rebreathing, stroke volume (SV), arteriovenous oxygen difference (a-vO2 diff), and total peripheral resistance (TPR) were measured during submaximal (40,
60, 80 %) and maximal (∼ 100 % V·O2max) exercise. NOS3 G894T genotype was not significantly associated, either independently
or interactively with habitual physical activity (PA) level, with SBP, Q, TPR, or
a-vO2 diff during submaximal or maximal exercise. However, NOS3 894T non-carriers had a
higher submaximal exercise HR than NOS3 894T allele carriers (120 ± 2 vs. 112 ± 2
beats/min, p = 0.007). NOS3 894T allele carriers had a higher SV than 894T non-carriers
(78 ± 2 vs. 72 ± 2 ml/beat, p = 0.03) during submaximal exercise. NOS3 894T non-carriers
also had a higher maximal exercise HR averaged across habitual PA groups than T allele
carrier women (165 ± 2 vs. 158 ± 2 beats/min, p = 0.04). NOS3 894T allele carriers
also tended to have a higher SV during maximal exercise than 894T non-carriers (70
± 2 vs. 64 ± 2 ml/beat, p = 0.08). NOS3 T-786C genotype was not significantly associated,
either independently or interactively, with any of the CV hemodynamic measures during
submaximal or maximal exercise. These results suggest an association of NOS3 G894T
genotype with submaximal and maximal exercise CV hemodynamic responses, especially
HR, in postmenopausal women.
Key words
Heart rate - cardiac output - stroke volume - genetics
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PhD James M. Hagberg
Department of Kinesiology, HHP Bldg Rm. 2134E
University of Maryland
College Park, MD 20742-2611 USA
Phone: + 3014052487
Fax: + 30 14 05 55 78
Email: hagberg@umd.edu
