We studied the Pd(0)-catalyzed Suzuki-Miyaura cross-coupling reaction and obtained
an improved procedure with shorter reaction times and higher conversions.
We investigated two methods stepwise addition of reagents and addition of all the
reagents at the same time. We found that the reaction rate of the former is faster
than the latter. Methanol was shown to be the optimum solvent for the reaction, however
with an alcohol as the solvent the reaction was complete in under 1.5 hours. This
improved methodology was applied to the synthesis of novel fluorine-substituted 3-biaryl-1-ferrocene-propene-1-ones,
which were synthesized in good yields.
Suzuki cross-coupling reaction - Pd(0) catalyst - alcohol solvents - ferrocene derivatives
- biaryl