‘In situ’ Generated ‘HCl’ - An Efficient Catalyst for Solvent-Free Hantzsch Reaction at Room Temperature: Synthesis of New Dihydropyridine Glycoconjugates

G. V. M. Sharma; K. Laxmi Reddy; P. Sree Lakshmi; Palakodety Radha Krishna

doi:10.1055/s-2005-921744

PAPER

‘In situ’ Generated ‘HCl’ - An Efficient Catalyst for Solvent-Free Hantzsch Reaction at Room Temperature: Synthesis of New Dihydropyridine Glycoconjugates [1]

G. V. M. Sharma*, K. Laxmi Reddy, P. Sree Lakshmi, Palakodety Radha Krishna
D-211, Discovery Laboratory, Organic Chemistry Division-III, Indian Institute of Chemical Technology, Hyderabad-500 007, India
Fax: +91(40)27160387; e-Mail: esmvee@iict.res.in;

Abstract

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Abstract

HCl, generated in situ from 2,4,6-trichloro[1,3,5]triazine (TCT, cyanuric chloride), catalyzed a solvent free Hantzsch reaction at room temperature with enhanced reaction rates. The reaction conditions allow facile preparation of glycoconjugates of dihydropyridines under mild reaction conditions in high yields.

Key words

dihydropyridines - glycoconjugates - Hantzsch reaction - 2,4,6-trichloro[1,3,5]triazine (TCT - cyanuric chloride)

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References

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