Synthesis 2005(20): 3666-3671  
DOI: 10.1055/s-2005-918488
PSP
© Georg Thieme Verlag Stuttgart · New York

Multigram-Scale Asymmetric Hydrogenation Reactions Using Ru-SYNPHOS® and Ru-DIFLUORPHOS® Catalysts

Séverine Jeulina, Nicolas Championb, Philippe Dellisb, Virginie Ratovelomanana-Vidal*a, Jean-Pierre Genêt*a
a Laboratoire de Synthèse Sélective Organique et Produits Naturels (UMR 7573 CNRS), Ecole Nationale Supérieure de Chimie de Paris, 11 rue Pierre et Marie Curie, 75231 Paris Cedex 05, France
Fax: +33(1)44071062; e-Mail: jean-pierre-genet@enscp.fr; e-Mail: virginie-vidal@enscp.fr;
b SYNKEM S.A.S., 47 rue de Longvic, BP 50, 21301 Chenôve Cedex, France
Further Information

Publication History

Received 16 September 2005
Publication Date:
18 November 2005 (online)

Abstract

The detailed procedure for the synthesis of Ru-SYNPHOS® and Ru-DIFLUORPHOS® catalysts are described. These catalysts displayed high rates and are quite effective for the large-scale hydrogenation reactions of unsaturated compounds.

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