Synthesis of the Tricyclic Core of the Marine Natural Product Labiatin A

Abstract

A synthetic route to a model of the tricyclic core of labiatin A is described. Two catalytic metal carbenoid reactions, C-H insertion and oxonium ylide generation with subsequent [2,3]-sigmatropic rearrangement, have been used to assemble the tricyclic system in an efficient and stereoselective manner.

Key words

carbenoid - ylide - rearrangement - stereoselective synthesis - natural product

References

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