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Synfacts 2005(1): 0097-0097  
DOI: 10.1055/s-2005-872153
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Total Synthesis of Cribrostatin IV

Contributor(s): Philip Kocienski, John Cooksey
C. Chan, R. Heid, S. Zheng, J. Guo, B. Zhou, T. Furuuchi, S. J. Danishefsky*
Columbia University, New York, USA
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Publikationsdatum:
21. September 2005 (online)

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Significance

Cribrostatin IV is a potent cytotoxic agent isolated from a blue marine sponge Cribrochalina found in the reef passages off the Maldives. It is a member of the piperizinohydroisoquinoline alkaloids of current interest in the pharmaceutical industry.