Abstract
An expedient access to diverse N -alkyl 1,2,3,4-tetrahydroisoquinolines is reported by reductive amination of aldehydes
and ketones with tetrahydroisoquinoline (THIQ) in the presence of Ti(Oi -Pr)4 and NaBH4 . The N -alkyl THIQ products were rapidly purified by flow-through catch and release technique
using commercially available polymer-supported sulfonic acid, MP-TsOH columns.
Key Words
reductive amination - tetrahydroisoquinoline - Ti(Oi -Pr)4
- NaBH4
- polymer-supported sulfonic acid column
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