Abstract
A series of 1,4-dihydropyridines were synthesized in an environmentally benign method,
by reacting aldehydes with acetoacetate esters or acetylacetone and ammonium acetate
in refluxing water. The thus formed 1,4-dihydropyridines was subsequently oxidized
in one-pot to the corresponding pyridine derivatives by either ferric chloride or
potassium permanganate.
Key words
1,4-dihydropyridines - pyridines - aromatization - aqueous-phase synthesis
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