A General and Facile Route to New Trisubstituted Purin-8-ones

Abstract

A facile general route was developed to synthesise new trisubstituted purin-8-one derivatives starting from cheap and readily available 5-bromouracil. These fused planar heterocycles present key hydrogen bond donating/accepting functionalities, making them interesting scaffolds for binding to biological targets.

purin-8-ones - fused-ring systems - nucleophilic aromatic substitution - ring-closure - microwave-assisted synthesis

References

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