InCl3-HMTA as a Methylene Donor: One-Pot Synthesis of Diindolylmethane (DIM) and Its Derivatives

Prasun K. Pradhan; Sumit Dey; Venkatachalam Sesha Giri; Parasuraman Jaisankar

doi:10.1055/s-2005-869897

PAPER

InCl₃-HMTA as a Methylene Donor: One-Pot Synthesis of Diindolylmethane (DIM) and Its Derivatives

Prasun K. Pradhan, Sumit Dey, Venkatachalam Sesha Giri, Parasuraman Jaisankar*
Department of Medicinal Chemistry, Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Jadavpur, Calcutta-700032, India
Fax: +91(33)24735197; e-Mail: jaisankar@iicb.res.in;

Abstract

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Abstract

Treatment of indoles 1a-k with hexamethylenetetramine (HMTA) (2) in presence of a catalytic amount (10 mol%) of InCl₃ resulted in 3,3′-diindolylmethane (DIM) derivatives 3a-k in excellent yields.

Key words

indium trichloride - catalyst - hexamethylenetetramine (HMTA) - diindolylmethane (DIM) - dietary supplement - anti-cancer

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References

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