A Novel Method for the One-Pot Three-Component Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones

Peyman Salehi; Minoo Dabiri; Mohammad Ali Zolfigol; Mostafa Baghbanzadeh

doi:10.1055/s-2005-865200

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Synlett 2005(7): 1155-1157
DOI: 10.1055/s-2005-865200

LETTER

A Novel Method for the One-Pot Three-Component Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones

Peyman Salehi*^a, Minoo Dabiri^b, Mohammad Ali Zolfigol^c, Mostafa Baghbanzadeh^b
^a Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, P.O. Box 19835-389, Evin, Tehran 1983963113, Iran
e-Mail: p-salehi@sbu.ac.ir;
^b Department of Chemistry, Faculty of Science, Shahid Beheshti University, Evin, Tehran 1983963113, Iran
^c Department of Chemistry, Faculty of Science, Bu-Ali Sina University, Hamadan 65174, Iran

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Publication History

Received 8 December 2004
Publication Date:
14 April 2005 (online)

Abstract
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Abstract

One-pot three-component condensation of isatoic anhydride with primary amines or ammonium carbonate and aromatic aldehydes in refluxing ethanol in the presence of catalytic amounts of silica sulfuric acid afforded the corresponding 2,3-dihydroquinazolin-4(1H)-ones in high yields. The catalyst is reusable and can be applied several times without any decrease in product yield.

Key words

silica sulfuric acid - heterocycles - 2,3-dihydroquinazolin-4(1H)-ones - catalysis - isatoic anhydride

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