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Synlett 2005(6): 0986-0990
DOI: 10.1055/s-2005-864823
DOI: 10.1055/s-2005-864823
LETTER
© Georg Thieme Verlag Stuttgart · New YorkThe Influence of Acidity on Direct Aldol Reactions Catalyzed by Pyrrolidine/Acid Bifunctional Organocatalyst
Further Information
Received
3 November 2004
Publication Date:
23 March 2005 (online)
Publication History
Publication Date:
23 March 2005 (online)
Abstract
The match of the acidity and basicity is very important to obtain good reactivity and high yield in the pyrrolidine/acid bifunctional organocatalyst system. The combination of pyrrolidine/p-nitrophenol was a high efficiency catalyst, which has been employed in the direct aldol reaction of aldehydes and ketones with yields up to 99%.
Key words
acidity - aldol reaction - pyrrolidine - p-nitrophenol - bifunctional catalysis
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