An Efficient and Diastereoselective Synthesis of trans β-Lactams and β-Aminocarbonyl Compounds

Abstract

Efficient and diastereoselective syntheses of trans β-lactams and anti β-aminocarbonyl compounds from carboximide 1 and imines 2 under the classical Reformatsky reaction conditions are described. An enolate-imine mechanism has been proposed for this reaction.

Key words

β-lactams - imines - Reformatsky reaction - β-aminocarbonyl compounds

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