A Total Synthesis of the Aromatic Monoterpene Espintanol

Adrián Covarrubias Zúñiga; Moisés Romero-Ortega; José G. Avila Zárraga

doi:10.1055/s-2004-837305

SHORTPAPER

A Total Synthesis of the Aromatic Monoterpene Espintanol

Adrián Covarrubias Zúñiga*^a, Moisés Romero-Ortega^b, José G. Avila Zárraga^c
^a Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, México
e-Mail: adriancz@servidor.unam.mx;
^b Facultad de Química, Universidad Autónoma del Estado de México, Paseo Colón-Paseo Tollocan, Toluca, Estado de México, México
^c Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, D. F., México

Abstract

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Abstract

A synthesis of the leishmanicidal and trypanocidal monoterpene espintanol from dimethyl 2-isopropyl-3-oxoglutarate and 2-butynal using a Michael addition-Dieckmann cyclization as the key step is described.

Key words

monoterpene - leishmanicidal - trypanocidal - cyclization - total synthesis

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References

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