Homeostatic Model Assessment and Risk for Hypertension During Pregnancy: A Longitudinal Prospective Study

ABSTRACT

The propose of this study was to determine the association between insulin resistance and hypertension during pregnancy with the homeostatic model assessment (HOMA-IR). A longitudinal prospective study was carried out. One hundred sixty normotensive pregnant women were followed from the first trimester until delivery. HOMA-IR levels were determined each trimester. Statistical analysis included one-way analysis of variance and multivariate logistic regression. At follow-up, 134 women (83.8%) remained normotensive, 18 (11.2%) developed gestational hypertension, and 8 (5%) developed preeclampsia. At first trimester, HOMA-IR levels were higher in women who developed gestational hypertension (2.1 ± 0.2) than in women who developed preeclampsia (1.2 ± 0.0), or remained normotensive (1.2 ± 0.3); p < 0.01. In the logistic regression analysis, HOMA-IR levels at first trimester were statistically significant (p = 0.03) to predict development of gestational hypertension. Our results support the use of the HOMA-IR as an alternative index for the assessment of the risk for hypertension during pregnancy.

KEYWORDS

Gestational hypertension - insulin resistance - preeclampsia

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