Synthesis of 2,3-Disubstituted Benzofurans from ortho-Acylphenols

Kwang-Ok Kim; Jinsung Tae

doi:10.1055/s-2004-834951

PAPER

Synthesis of 2,3-Disubstituted Benzofurans from ortho-Acylphenols

Kwang-Ok Kim, Jinsung Tae*
Center for Bioactive Molecular Hybrids (CBMH) and Department of Chemistry, Yonsei University, Seoul 120-749, South Korea
Fax: +82(2)3647050; e-Mail: jstae@yonsei.ac.kr;

Abstract

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Abstract

2,3-Disubstituted benzofuran derivatives were synthesized from ortho-acylphenols in two steps. The β-aryloxyacrylates prepared from the ortho-acylphenols were treated with n-Bu₃SnH/AIBN and then with 5% HCl-EtOH to afford 2,3-disubstituted benzofurans.

Key words

benzofurans - cyclizations - dehydrations - phenols - radical reactions

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References

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