Hexafluoroacetone as Protecting and Activating Reagent: Site-Selective Functionalization of α-Amino Alkanedioic Acids

Abstract

Methodology for the site-selective functionalization of α-amino alkanedioic acids (Asp, Glu and homologues) using hexa­fluoroacetone as protecting and activating reagent is described. Via new types of dielectrophiles, alternative approaches to multifunctional non-natural amino acids and some of their conjugates become readily available.

hexafluoroacetone - fluorine - DAST - diacylation - ω-carboxy-activation - amino acids

References

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