Peptide-bridged dicatechols were prepared by a combination of solid- and solution-phase
synthesis. The target compounds are potential precursors for constrained metal containing
enkephalin analogs. While a simple model compound selectively forms a metallamacrocycle
with the cis-molybdenum(VI)dioxo unit, this goal could not be achieved with the corresponding
peptide bridged derivatives.
peptides - solid-phase synthesis - enkephalin - macrocycles - phenols