Abstract
A diastereoselective approach to 2,5-substituted decahydroquinolines by zirconium-mediated
cyclization of unsaturated α,α′-disubstituted piperidines II is described. The required piperidines could be obtained from secondary sulfonamides
III via ruthenium-catalyzed ring-rearrangement metathesis (RRM) in high yields. Racemic
trans -195A and 2-epi-trans- 195A were synthesized in 8 steps starting with butyraldehyde and cyclohex-2-enol.
Key words
metathesis - ruthenium - piperidines - zirconium - decahydroquinolines
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