Synthesis 2004(15): 2441-2444  
DOI: 10.1055/s-2004-831233
PAPER
© Georg Thieme Verlag Stuttgart · New York

Simple, Efficient and One-Pot Method for Synthesis of Aminomethylene gem-Diphosphonic Acid Derivatives from Ketones via Beckmann Rearrangement

Mingshu Wu, Ruyu Chen*, You Huang*
Institute and National Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China
Fax: +86(22)23503438; e-Mail: wums@eyou.com;
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Publication History

Received 1 March 2004
Publication Date:
22 September 2004 (online)

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Abstract

A simple, expeditious and convenient synthesis of aminomethylene gem-diphosphonic acid derivatives in one-pot reaction using ketones, hydroxylamine hydrochloride, phosphorus trichloride and water as starting materials in the presence of pyridine via Beckmann rearrangement is described in the modest yields.